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Further information is available via NHS medicines information pages and NICE guidance at nice.org.uk
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In the larger SELECT trial in 2023, patients with heart failure, atherosclerotic disease, and overweight or obesity, treated with semaglutide 2.4 mg showed reduction in major adverse cardiac events (MACE) and heart failure end points regardless of heart failure subgroup being HFrEF or HFpEF [56,57,58]
In diabetes, endocrine factors also increase potassium levels
Kisspeptin increases GnRH, which increases FSH and LH, promoting follicle development and sperm production
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