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Most patients notice visible improvement in skin brightness and clarity within 24 weeks of regular treatments

Weight loss during this period is often modest, perhaps 1 to 3 pounds, because the dose is below the threshold where all three receptors are fully engaged

Most information comes from patient forums and social media, where reports are mixed: some describe renewed appetite suppression on re-start, while others report weight gain during breaks and significant nausea on resuming previous doses, often requiring a full re-titration

Famularo, G., et al

Compare that with SGLT2 inhibitors such as Jardiance or Farxiga, which are paused to avoid a metabolic problem called ketoacidosis