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Since APAP is responsible for nearly half of the cases of acute liver failure in the United States and remains the leading cause for liver transplantation, continued awareness, education and research should be undertaken

In general, damage occurs in hepatocytes as they metabolize the paracetamol

namely, dihydroxyphenylalanine, dityrosine and a cross-linked residue consistent with a hydroxylated dityrosine residue 26

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