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The Levels of Polyamines in Autopsy Materials of Some Structures of Brain Lymbic System and Reticular Formation of Patients with Schizophrenia

Pairing them is hypothesized not proven to give broader coverage than either alone

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Additional risk factors include: Chronic kidney disease : Reduced renal clearance may impair B12 excretion Liver disease : Hepatic dysfunction can disrupt B12 metabolism and storage Myeloproliferative disorders : Certain blood cancers increase B12-binding proteins Concurrent medication use : Some drugs may interact with B12 metabolism, including metformin, proton pump inhibitors, and H2 antagonists Patients with these conditions should have B12 supplementation carefully monitored by their healthcare team

Initial investigations focused on the metabolic stability of various Nle-AngIV-derived peptides in rat serum