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[2] [3] If you are taking warfarin or other coumarin anticoagulants, the MHRA SmPC advises that INR monitoring should be performed when initiating semaglutide treatment

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Comparative example 1 (1) The following peptide resins were prepared according to the procedure of example 1: H-Lys 20 (AEEA-AEEA--Glu(OtBu)-Octadecanedioic)-Glu 21 (OtBu)-Phe 22 -Ile 23 -Ala 24 -Trp 25 (Boc)-Leu 26 -Val 27 -Arg 28 (pbf)-Gly 29 -Arg 30 (pbf)-Gly 31 -Wang resin (2) coupling and deprotection were repeated according to the methods of example 1, steps 4 and 5, using HOBT/DIC as a condensing agent and DMF as a solvent, and protected amino acids Fmoc-Ala-Ala-OH, Fmoc-Gln (Trt) -OH, Fmoc-Gly-OH, Fmoc-Glu (OtBu) -OH, Fmoc-Leu-OH, Fmoc-Tyr (tBu) -OH, Fmoc-Ser (tBu) -OH, Fmoc-Val-OH, Fmoc-Asp (OtBu) -OH, Fmoc-Ser (tBu) -OH, Fmoc-Thr (tBu) -OH, Fmoc-Phe-OH, Fmoc-Thr (tBu) -OH, Fmoc-Gly-OH, Fmoc-Glu (OtBu) -OH and Fmoc-Aib-OH were sequentially connected, each amino acid charge was 3 times the molar number of Fmoc-Gly-Wangrestin, the following peptide resins were obtained: Fmoc-Aib 2 -Glu 3 (OtBu)-Gly 4 -Thr 5 (tBu)-Phe 6 -Thr 7 (tBu)-Ser 8 (tBu)-Asp 9 (OtBu)-Val 10 -Ser 11 (tBu)-Ser 12 (tBu)-Tyr 13 (tBu)-Leu 14 -Glu 15 (OtBu)-Gly 16 -Gln 17 (Trt)-Ala 18 -Ala 19 --Lys 20 (AEEA-AEEA--Glu(OtBu)-Octadecanedioic)-Glu 21 (OtBu)-Phe 22 -Ile 23 -Ala 24 -Trp 25 (Boc)-Leu 26 -Val 27 -Arg 28 (pbf)-Gly 29 -Arg 30 (pbf)-Gly 31 -Wang resin (3) pouring six parts of the peptide resin prepared in the step (2) into a solid phase reactor respectively, removing Fmoc protection according to the method of the embodiment 1, and washing