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La proteccin de las macromolculas celulares frente a las especies de oxgeno y nitrgeno reactivas endgenas y exgenas es una de sus funciones vitales

Because Pycnogenol relies heavily on the gut microbiome to produce its most potent neuroprotective metabolite (M1), patients with severe gut dysbiosis or those currently on broad-spectrum antibiotics may experience slightly reduced efficacy until their gut flora is restored

Fras JP, Davies MJ, Rosenstock J, Manghi FCP, Land LF, Bergman BK, et al

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However, recent studies have linked this medication to rare but serious eye conditions, such as non-arteritic anterior ischemic optic neuropathy (NAION), which can lead to sudden vision loss in one eye