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158 Conversely, a clinical trial investigating intravenous or intragastric alcohol administration reported no significant alterations in plasma GLP-1 concentrations in healthy male volunteers

This dual action has been shown in clinical trials to produce significant reductions in HbA1c (a marker of long-term blood glucose control) and body weight, often outperforming medications that target only one hormone pathway

In animal models, MOTS-c restored insulin sensitivity in aged and high-fat-fed mice at the muscle level - the same tissue where late-stage GLP-1 protocols often see metabolic slowdown

In addition, several GLP-1RA have been shown to reduce a composite 3-point MACE outcome in large, randomized cardiovascular outcome trials

Co-administration of pramlintide with either the sympathomimetic sibutramine or phentermine was observed to result in 9.2 kg weight loss compared with placebo over 24 weeks, whereas pramlintide monotherapy resulted in just 1.5 kg additional weight loss [79]