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For glycemic control in type 2 diabetes, improvements in blood glucose levels typically begin within the first week of treatment, with fasting glucose reductions often noticeable within 24 weeks

Eating every 2.5-3 hours maintains steady energy and prevents the blood sugar swings that can worsen symptoms

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During this process the PDI enzymes are themselves oxidized, requiring ER-localized GSH to carry out their reduction back to a function state