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As mentioned above, a GLP-1 receptor agonist works by mimicking the natural incretin hormone (hormones secreted by the gut) GLP-1, which may assist in lowering blood sugar in the following ways 7 , 8 : Increase insulin when blood glucose (sugar) is high: They enhance the bodys ability to release insulin when blood sugar levels are elevated

The medication's effect on gastric emptying can exacerbate pre-existing gastroesophageal reflux disease (GERD), potentially causing retrosternal burning or pressure that mimics cardiac symptoms

Maintenance dosing after goal weight is reached typically drops to 0.51ml every 1014 days

A 52-week phase 2 trial on AMG133 in people with overweight and obesity is ongoing (NCT05669599)

Bariatric surgery shows more promise for providing weight loss