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Myers KM, Carlezon WA, Davis M

No human-lifespan evidence There is no controlled trial demonstrating that Epithalon increases mean lifespan, maximum lifespan or disability-free survival in people

A 2009 paper in Archives of Dermatological Research observed that copper-bound GHK increased integrin expression and p63-positive keratinocyte counts in cell-culture experiments, framing one route by which the compound engages the dermal stem-cell compartment (PMID 19319546)

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The peptide affects the nitric oxide system, which could theoretically interact with blood pressure medications or other cardiovascular drugs