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At the enzyme level, 5-Amino-1MQ inhibits NNMTs methylation of nicotinamide reducing intracellular 1-MNA levels and diverting nicotinamide back into the NAD+ salvage pathway (via NAMPT-mediated conversion to NMN and subsequently NAD+)
For now, we should continue to follow the Black Box Warning: those individuals with a family or personal history of MTC or MEN2 should avoid GLP-1 RAs until we have a greater understanding of what is happening in the human thyroid c-cells
2023 Jan 1;78(1):75-89
Stern RS, Zierler S, Parrish JA
Bruin JE, Saber N, Braun N, et al
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