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They also revved up your heart

A 2026 analysis found that even brief interruptions in GLP-1 therapy were associated with elevated cardiovascular risk

Journal of Clinical Orthopaedics and Trauma , 15, 145151

This can lead to aching, leg swelling, heaviness, and throbbing in the legs

Practical Steps for Starting Semaglutide with a Thyroid Condition Before beginning any GLP-1 therapy, patients with thyroid disease should confirm their TSH and thyroid antibodies (TPO, thyroglobulin) are stable and well-documented