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When HFSCs receive Wnt signals, the -catenin signaling pathway is activated, causing HFSCs to switch from a quiescent state to a proliferative state, initiating the regeneration program (Hsu et al., 2011
In conclusion of this experiment the peptide exhibited virtually no effect on the development of spontaneous tumors in rats exposed to standard and constant illumination, but significantly inhibited their development in rats exposed to natural light
Immunofluorescence staining also showed a marked increase in the number of Ki-67-positive cells and a decrease in the nuclear content of -H2AX and P21 after FOXO4-DRI treatment (Figures 4B,C)
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