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Lee DH, Jacobs DR Jr, Steffes M
The glucagon receptor activation drives hepatic fat oxidation in ways that dual agonists do not replicate
By target indication, the type 2 diabetes segment held a major market share of approximately 55% in 2025
This strategy supports sustained benefits over extended use rather than short-lived gains
Moreover, because GLP-1R is expressed throughout the body, stimulation with a GLP-1R agonist or indirectly with a DPP-IV inhibitor can have a broad systemic effect on systemic metabolism, which, in turn, ameliorates peripheral and central insulin resistance in AD and MD (Athauda and Foltynie, 2016)
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