[4] [6] This relationship is bidirectional and complex, involving: Inflammatory pathways that affect both metabolic and mental health Hormonal dysregulation impacting mood and stress responses Psychosocial factors including stigma, body image concerns, and chronic disease burden Lifestyle factors such as reduced physical activity and poor sleep quality When GLP-1 medications improve glycaemic control, facilitate weight loss, and enhance overall metabolic health, patients may experience secondary improvements in psychological wellbeing
Rose K, Wan C, Thomas A, Seeram NP, Ma H (2018) Phenolic compounds isolated and identified from amla (Phyllanthus emblica) juice powder and their antioxidant and neuroprotective activities
Surgical procedures or acute illness Healthcare providers may recommend individualizing tirzepatide management before procedures based on the patient's symptoms, procedure type, and anesthesia risk
HFD inhibits the transcription of key antioxidant genes by triggering NRF2 translocation into obese mouse Tregs nucleus, causing a rapid decline in HO-1 expression in Tregs, leading to enhanced oxidative stress and possible ferroptosis, and causing an intensification of obesity and inflammatory responses (156) ( Figure 3 )
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