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FIGURE 4 Further analysis of the trajectory suggests that the several important amino acids, such as H7, E9, T11, F12, D15, and F28 of GLP-1 actively interact with the W 39 , Y 145 , Y 152 , R 190 , K 197 , L 201 , N 300 , R 310 , E 364 , L 384 , and L 388 of GLP-1R through several hydrogen, hydrophobic, and electrostatic interactions (Figure 5
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This binding activates adenylyl cyclase, increases intracellular cAMP, and triggers pulsatile synthesis and release of endogenous human growth hormone (GH) in a manner that mimics the bodys natural episodic secretion