Skin may feel firmer to the touch, fine lines may appear softer, and overall skin quality often improves
The largest of these (still fairly small, n=159) was a randomized and controlled clinical trial published in the New England Journal of Medicine , and found that a dose of 100 mcg twice per day improved quality of life, reduced eye involvement, and slowed disease progression among participants with mild Graves' orbitopathy (compared to pentoxifylline or placebo)
Hermann A, Janky R, Dohovics R, Saransaari P, Oja SS, et al
MaghsoudniaNEdalatMHajimolaaliMIranpourSKhoshkhatPInanlooPet al
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