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Besides the extended life span, the overexpression of histone proteins may also be associated with increased DNA expression and repair because irradiation-induced DNA damage was shown to downregulate histone gene transcription via the G1 checkpoint pathway 77

This is a major reason why it is viewed as a safer alternative to full growth hormone

Timing Follow-up Marker Fasting glucose Why it matters IGF-related activity can affect glucose handling, so current glucose context matters

It is a small-molecule NNMT inhibitor