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In the ACHIEVE-2 trial (Phase 3, 962 adults with type 2 diabetes on metformin), Orforglipron, a novel small-molecule oral GLP-1 RA went head-to-head against Dapagliflozin, one of the most widely used SGLT2 inhibitors
Often referred to as a smart hormone, GLP-1 is a naturally occurring peptide primarily produced in your large intestine
The efficacy signal is impressive
Michalakeas CA, Parissis JT, Douzenis A, Nikolaou M, Varounis C, Andreadou I, Antonellos N, Markantonis-Kiroudis S, Paraskevaidis I, Ikonomidis I, Lykouras E, Kremastinos D (2011) Effects of sertraline on circulating markers of oxidative stress in depressed patients with chronic heart failure: A pilot study
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