Sleep quality is typically the first noticeable change
Fatigue during tirzepatide therapy stems from rapid metabolic shifts as your body adjusts to dual GLP-1 and GIP receptor signaling
Brain Res Bull 180:5972 Yao F, Luo Y, Chen Y, Li Y, Hu X, You X et al (2023) Myelin debris impairs tight junctions and promotes the migration of microvascular endothelial cells in the injured spinal cord
Benefits of Semaglutide Reduces food intake by lowering appetite Promotes satiety and fullness by slowing food digestion in the stomach Decreases body fat percentage through loss of visceral adipose tissue and belly fat Weight loss with decreased waist size (majority of patients lost at least 15% bodyweight) Improves cardiovascular risk profile including lowering cholesterol, inflammation, blood pressure and blood sugar Lowers HbA1c Enhances growth of B cells in the pancreas Prevents cognitive decline Side effects can include: Nausea, Vomiting, Abdominal Bloating, Lack of appetite, Diarrhea, and Constipation
Liraglutide Injections Liraglutide injections like Saxenda were among the earliest GLP-1 medications used for obesity treatment and are still effective for appetite reduction and gradual weight loss
