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In line with these data, the GLP-1R has been found to be co-expressed in ARC POMC neurons in both rats (Sandoval et al., 2008) and mice (Ronnekleiv et al., 2014) suggesting that GLP-1 can act directly on these neurons

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"GLP-1 medications are a newer and very effective method of treating obesity as well as conditions such as Type 2 diabetes