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- Topical Analgesics Lidocaine patches, menthol-based creams, or capsaicin may help reduce localized pain

They participate in oxidative damage, regulate TJ modification, and activate inflammatory factors, and thus play a crucial role in the various mechanisms of BBB damage, including the kinin system, excitatory toxicity from toxic glutamate efflux, neutrophil recruitment, mitochondrial changes, and macrophage/microglial activation [106, 107]

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An automated 14:10 hour light-dark cycle, incorporating 30-minute brightening and dimming periods, was maintained [2]

Most people experience minimal side effects at the starting dose