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Narcotic pain medications, also called opioids, are strong pain medications but are generally avoided because they do not usually relieve fibromyalgia pain

Diminishing returns typically occur when receptors become downregulated or desensitized

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Interestingly, vehicle-fed 5XFAD mice were clearly impaired in their ability to distinguish the novel object, whereas 5XFAD mice treated with Hex behaved very similar to the non-Tg mice with increased preferences for the novel object (Supplemental Figure 4B)

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