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The BBB mechanism underlying water exchange (Kw) and Ktrans (related to contrast agent transfer) is likely to be different (Shao et al., 2020), since the first relates to permeability to water and the latter to GBCA

Funding This work was supported by the National Natural Science Foundation of China [grant number 82074206], the Science and Technology Innovation Action Plan of Shanghai Science and Technology Commission [grant number 21Y21920500] and Changhai Hospital Gu Hai plan

Some researchers tilt their head slightly back during administration to maximize mucosal contact

Lot CP-1321346 was tested by an independent laboratory

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