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GLP-1 (glucagon-like peptide-1) medications are a class of FDA-approved treatments originally developed for type 2 diabetes that have revolutionized medical weight loss

The shuttle involves two different glycerol-3-phosphate dehydrogenases: one is cytosolic (GPD1), acting to produce glycerol-3-phosphate, and one is an integral protein (GPD2) of the inner mitochondrial membrane that acts to oxidize the glycerol-3-phosphate produced by the cytosolic enzyme