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Screening may be warranted in patients with one or more risk factors, such as gastric or small intestine resections, inflammatory bowel disease, use of metformin for more than four months, use of proton pump inhibitors or histamine H 2 blockers for more than 12 months, vegans or strict vegetarians, and adults older than 75 years
and the Giorgio Foundation
492 The E3 ligases TRAF2 and TRAF6 play a central role in this process, linking the UPS to RA pathogenesis
Rev Clin Pharmacol Drug Ther
Pregnancy Pregnancy Category C Adequate and well-controlled studies have not been done in pregnant women
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