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Future research should focus on defining the magnitude of benefit in advanced CKD, elucidating additive or synergistic effects with other nephroprotective agents, and assessing long-term outcomes beyond traditional renal endpoints

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Comparing Side Effects Like many medications, semaglutide and tirzepatide can cause side effects, particularly during dose increases

Risk of bias assessment The risk of bias of the included studies was assessed independently by paired reviewers according to a modified Cochrane risk of bias tool [22]