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Clinical studies, including the STEP 1 trial extension, have demonstrated that patients who discontinue GLP-1 receptor agonists often regain a substantial portion of the weight they lost, sometimes within months

And then going back to studies on weight

Who Should Take Semaglutide for Weight Loss The FDA approved semaglutide specifically for chronic weight management in certain patients: BMI 30 kg/m^2 (obesity) BMI 27 kg/m^2 plus at least one weight-related health issue like type 2 diabetes or hypertension Those with a history of certain medical conditions should not take semaglutide: Multiple endocrine neoplasia syndrome type 2 (MEN 2) Medullary thyroid carcinoma Severe gastrointestinal disease Always consult a healthcare professional before starting semaglutide

That means you could be looking at a long-term financial commitment

Potent low toxicity Inhibition of human melanogenesis by novel indole-containing octapeptides