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Obstruccin intestinal : Se han descrito casos de leo paraltico y obstruccin intestinal funcional relacionados con el efecto del GLP-1 sobre el vaciado gstrico y la motilidad intestinal

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Glucagon-like peptide 1 (GLP-1) can reverse AMP-activated protein kinase (AMPK) and S6 kinase (P70S6K) activities induced by fluctuations in glucose levels in hypothalamic areas involved in feeding behaviour

Ayoub E, Lehotzky D, Li L, Muftuoglu M, Nishida Y, Mohanty V, Leighton JS, Patsilevas T, Basyal M, Bedoy A, Haftarah T, Takahashi K, Chen K, Navin N, Issa GC, Getz G, Andreeff M

This result is consistent with the finding that cAMP signaling serves as the amplification pathway in pancreatic -cells