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This peptide-metal complex can be endogenously generated in mammalian systems through proteolytic processing of larger precursor proteins
The key differences: TRIUMPH-1 had a lower discontinuation rate (11.3% vs 18.2%) and included a 104-week extension showing 30.3% weight loss
The difference in effectiveness could be attributed to tirzepatides GIP agonism and its more robust ability to promote weight loss
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Clinical studies, patient outcomes, and comparisons with other treatments all support its use
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