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Randomized withdrawal trials and off-treatment extensions recorded substantial average weight regain after semaglutide or tirzepatide was withdrawn

Clin Pharmacol Ther 83:368371 Amacher DE (1998) Serum transaminase elevations as indicators of hepatic injury following the administration of drugs

Weight-focused users tend to stay on the drugs for shorter periods of time, with only 44% continuing to use them after one year, compared with nearly 70% of those using the medications for other health conditions

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This is less about pharmacology and more about psychology