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The Science Behind Sculptra Once injected, Sculptra initiates a controlled inflammatory response that activates fibroblasts within the dermis

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Thus, TLR2/TLR4 activation promotes the dissociation of the inhibitor of nuclear factor kappa-B (I-B)/NF-B complex through a myeloid differentiation primary response 88-dependent (MyD88) signaling pathway, mediating the nuclear translocation of nuclear factor kappaB (NF-B) and specifically acting on the NLRP3 and IL-1B gene promoter regions

The underlying reason is in the FDA label: cases of acute kidney injury have been reported, some requiring hemodialysis, mostly in people whose gastrointestinal reactions such as nausea, vomiting, or diarrhea led to dehydration