However, CMS has clarified that the currently used USP guidelines do not include categories and classes of drugs for anorexia, weight loss, or weight gain and these drugs are not required to be covered under EHB rules

FDA's 2026 GLP-1 Warnings: 990 Reports and What They Mean for JoinSkinny Patients FDA has published ongoing warnings about compounded GLP-1 products generally: Dosing errors from measuring doses out of multi-dose vials Use of salt forms (like semaglutide sodium) that haven't been proven safe or effective Adverse events, including hospitalization in some cases As of May 31, 2026: 990 adverse-event reports tied to compounded semaglutide, and more than 730 tied to compounded tirzepatide - FDA notes these reports may be incomplete and don't, by themselves, establish that a compounded drug caused the reported event On April 30, 2026: FDA proposed excluding semaglutide, tirzepatide, and liraglutide from the 503B bulks list - a move that would close the main legal pathway for large-scale outsourcing-facility compounding of these drugs absent a shortage, with a public comment period that ran through June 29, 2026 These are industry-wide regulatory developments, not findings against JoinSkinny or any specific pharmacy named in this article

In 2025, the World Health Organisation added semaglutide and other GLP-1 medicines to its Model List of Essential Medicines for selected patients with type 2 diabetes who also have cardiovascular disease, chronic kidney disease or obesity
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Nausea and side effects often peak 23 days after a dose increase before stabilizing