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10.1038/cddis.2012.83 55 DenicolaG
Mao found that treating cancer cells with GPX4 inhibitors resulted in acute depletion of N-carbamyl-L-aspartate (C-ASP, a pyrimidine biosynthesis intermediate), accompanied by accumulation of uridine, which could be inhibited by fer-1, a ferroptosis inhibitor [18]
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During the transition window, some patients experience temporary hunger return or mild side effects as their system adjusts to the new medication
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