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In the acute stress phase, neutrophilia occurs, and there is an increase in NK cells in the plasma, in addition to proinflammatory cytokine imbalance, with an increase in IL6, resulting from the secretion of cortisol and catecholamines, modulating the immune response and the development of autoimmune and autoinflammatory diseases.106 Emerging therapies The three emerging vitiligo therapeutic classes that are at the most advanced stage of development and are associated with the most important pathogenic pathways are the tyrosine kinase inhibitors (e.g., JAK1, JAK2, JAK3, TYK2), anti-IL15, and mutant HSP70.74,88,107Table 3 shows the emerging drugs according to their pathophysiological target

Deciphering relationship between depression and microbial molecules based on multi-omics: a case study of Chaigui Granules

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