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In a recent double-blind, randomized, placebo-controlled trial in women with abnormal mammograms, two-to-eight week consumption of about 250 mg/day of broccoli seed extract (~220 mg of glucoraphanin/day) before surgery failed to affect the expression of markers of proliferation and gene expression, including ki-67, p21, HDACs, and acetylated histones, in breast tissues collected after surgery (62)

Evidence base : Semaglutide has been studied in large, randomized controlled trials involving tens of thousands of patients, with well-established safety and efficacy profiles

(download DOCX Summary of LEADER model, including full details of the baseline variables considered in the model

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