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At the same time, insulin secretion is not activated under normal or low glucose conditions, preventing excessive blood sugar drops (45)

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According to the data, interest in semaglutide also ballooned in this period, with the agent accounting for more than 88% of new GLP-1 receptor agonist prescriptions in 2023

When adverse effects occurred, they were typically mild and transient, with the most common being mild to moderate headaches (similar frequency to placebo groups), minor injection site reactions (redness, slight swelling), and gastrointestinal effects at higher oral doses (nausea, diarrhea)