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Effect of Subcutaneous Tirzepatide vs Placebo added to titrated insulin glargine on Glycemic Control in patients with type 2 diabetes: the SURPASS-5 Randomized Clinical Trial
Despite the flexibility within the N-terminal two residues, Glu3 of exendin-4 formed very similar contacts to that of Glu9 of GLP-1, however, interactions with residues residing at the base of the pocket were more transient for exendin-4 (7580% of the MD frames) than for GLP-1 in the MD simulations (97% of frames for Y152 1.47 and 100% for R190 2.60 ) (Supplementary Table 3)
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JAK inhibitors (tofacitinib, upadacitinib) and the S1P receptor modulator ozanimod are also approved for use in appropriate patients with moderate-to-severe UC when conventional therapy or biologics are not suitable or have failed
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