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Animal studies involving both GH-deficient and non-GH-deficient mice have shown that twice-daily ipamorelin injections lead to significant increases in body weight (15.3% and 16.9% respectively) [8] and stimulate GH secretion, which is lipolytic [9]

Manufacturers compensate by using peptide fragments or lipid-conjugated peptides that absorb more readily, but these are workarounds, not solutions

Miller R, Buehner G, Chang Y, Harper JM, Sigler R, Smith-Wheelock : Methionine deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-1 and insulin levels and increases hepatocyte MIF levels and stress resistence

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