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Dihexa, chemically known as N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide, emerged from efforts to create a small molecule that retains the memory-enhancing properties of Nle-AngIV and its N-terminal fragments

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Other important safety considerations include maintaining adequate hydration to prevent acute kidney injury if experiencing severe gastrointestinal symptoms, monitoring for mood changes or suicidal ideation (particularly with Wegovy), and considering retinopathy monitoring in people with type 2 diabetes

The FDAs shortage designation essentially created a window of opportunity for compounding pharmacies