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GLP-1 boosts insulin secretion from pancreatic beta cells in a glucose-dependent manner (meaning it only works when blood glucose is elevated, reducing hypoglycemia risk), suppresses glucagon secretion from pancreatic alpha cells (reducing glucose production by the liver), slows gastric emptying (prolonging satiety and reducing postprandial glucose spikes), and starts GLP-1 receptors in the brain (very the hypothalamus) to reduce appetite and food intake

For individuals with low B12 levels or those who have difficulty absorbing B12, more frequent injections may be necessary to maintain optimal levels

doi:10.1055/s-0042-123038 [31] Ness-Abramof R, Nabriski DA, Braverman LE, et al

This reduction in NO availability negatively impacts both angiogenesis and vascular homeostasis

Application force also matters