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Semaglutide is a weight loss drug that targets the glucagon-like peptide-1 (GLP-1), sold by Novo Nordisk under the brand name Wegovy to treat people with obesity and under Ozempic to treat patients with both type 2 diabetes and obesity
Heart Rate: Glucagon agonism can transiently increase the heart rate
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The covariates included age (modelled as a continuous variable using cubic splines with five knots at the 5th, 27.5th, 50th, 72.5th, and 95th centiles), sex, smoking status, body mass index, alcohol related disorders, and cohort entry year (2013-15, 2016-18, 2019-21)
Compounded semaglutide: a different situation entirely Compounded semaglutide operates under fundamentally different rules
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