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Proposed mechanisms of MOTS-c: Activates AMPK Improves insulin sensitivity Enhances glucose utilization Increases metabolic flexibility Improves mitochondrial efficiency Supports exercise performance Why AMPK matters: AMPK is often called the body's metabolic master switch

G.P., Glutathione reductase: regulation and role in oxidative stress, in Oxidative stress and the molecular biology of antioxidant defenses

n = 13) or HFD ( n = 12) for 14 days and submitted to a 12-h light/dark cycle starting at 06:00

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The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1