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Many people with Alzheimers develop insulin problems in their brains, similar to diabetes

Phase 2 trial data (NEJM, 2023) reported a mean body weight reduction of approximately 24% over 48 weeks at the highest dose, though larger Phase 3 trials are needed to confirm these findings

Here are a few relevant concepts: Obesity is an inflammatory condition

The 2023 AHA/ACC Hypertension Guideline explicitly identifies GLP-1 receptor agonist therapy as a secondary cause of blood pressure reduction that may require antihypertensive de-escalation