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1d) demonstrated a distinct response pattern

While both medications may be prescribed by a licensed healthcare provider for PCOS management [13] , they work through different mechanisms: Metformin increases insulin sensitivity and may help stimulate ovulation [14] Semaglutide reduces glucagon secretion and decreases appetite Combined therapy might offer enhanced benefits for some patients [15] For patients who cannot tolerate metformin or haven't achieved desired results, compounded semaglutide presents a viable alternative

However, clear limitations also exist, including the reliance on the pre-existing microbiome composition for substrate processing, as well as potential off target effects, whereby a single substrate can be the precursor for multiple metabolites

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