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The reaction mixtures were manually mixed using a 100 to 300 l multichannel pipette (set to 250 l) and the microplate was inserted into a BioTek H1 Synergy microplate reader equilibrated to 37 C and vigorously shaken for 1 min followed by a 3.5-min delay

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Cardiovascular Outcomes with Semaglutide: The SUSTAIN-6 trial (Marso et al., 2016, New England Journal of Medicine ) revealed that semaglutide significantly reduced the risk of major adverse cardiovascular events, highlighting its benefits beyond glucose control

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