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When NNMT runs too high in fat tissue, it wastes a form of vitamin B3 that the body needs to make NAD+

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Researchers should understand this status and its implications for safety and legality

Contraindications Given the limited safety data, conservative contraindications would include pregnancy or plans to become pregnant, breastfeeding, age under 18, severe liver or kidney disease, and any condition requiring medications with unknown interaction potential

In studies examining muscle regeneration following injury, NNMT inhibition promoted stem cell activation and improved healing outcomes