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Additional exploratory post hoc analyses were conducted to explore the relationship between weight reduction and PROs using ANCOVA models with model terms treatment, weight change category, treatment-by-weight-change-category interaction and pooled country as fixed effects and baseline PRO score and baseline weight as covariates

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adults (based on National Health and Nutrition Examination Survey data) who are overweight or obese would fit SURMOUNT-1 eligibility criteria and that treatment with the drug would result in 55 million fewer persons with obesity based on the 15-milligram dosage