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Discontinuation is often due to gastrointestinal side effects, financial constraints, and limited access through insurance or prescribing guidelines

LDL cholesterol reductions of approximately 20% occurred consistently across studies, likely reflecting enhanced hepatic cholesterol clearance through glucagon-mediated upregulation of LDL receptors

doi: 10.1007/s12325-019-01101-6

doi:10.1186/s40101-018-0172-z

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