Candidates for supervised discontinuation: Maintained goal weight on a stable dose for 12 or more months Lost weight primarily through combined medication and lifestyle change (not medication alone) Consume 1.2 to 1.6 g protein per kg body weight daily Perform resistance training 3 or more times per week Sleep 7 or more hours nightly with good sleep architecture Have a BMI at goal of 25 or higher (patients who drop into the low-normal range have less metabolic buffer) No history of binge eating disorder or significant emotional eating patterns Even with this profile, the SURMOUNT-4 data suggests that roughly half of patients will regain meaningful weight within 12 months of stopping (Aronne et al., JAMA 2024)
The cost difference is the clinical infrastructure, not the compound alone
6-Week Tirzepatide Niacinamide Starter Program Weeks 12: 2.5 mg weekly, if prescribed by a licensed healthcare provider
A batch-specific COA is generated for the exact vial you are ordering, including the precise purity percentage, test results, and lab details
At the same time, insofar as the company promotes a kind of self-regulation within the peptide world, it also enhances the industrys legitimacy